Dedifferentiation in glioma

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs

The success of stem cell-mediated gene therapy in cancer treatment largely depends on the specific homing ability of stem cells. We have previously demonstrated that after in vitro induction of neuronal differentiation and dedifferentiation, bone marrow stromal cells (BMSCs) revert to a primitive stem cell population (De-neu-BMSCs) distinct from naive BMSCs. We report here that De-neu-BMSCs exp...

متن کامل

Mass dedifferentiation

he machine that is a cell is more than the sum of its protein parts. A large step toward understanding how those parts are so effectively put together has been taken by Patrick Aloy, Rob Russell (EMBL, Heidelberg, Germany), and colleagues. Their work has identified ‫ف‬ 100 yeast protein complexes and predicted interactions within and among many of them. " We were working on a large scale to mod...

متن کامل

RapidArc: Initial experience in high grade glioma

Background: Identify the optimal technique of radiotherapy for patients with high grade glioma. Our initial year of experience with RapidArc radiation therapy. Materials and Methods: Planning CT scans of 50 patients with grade IV glioma were reviewed and three plan sets by 3D Conformal Radiotherapy (3DCRT), Intensity Modulated Radiotherapy (IMRT) and Rapid Arc (RA) were generated and the plans ...

متن کامل

Explorer Dopamine and memory dedifferentiation in aging

1 The dedifferentiation theory of aging proposes that a reduction in the specificity of neural 2 representations causes declines in complex cognition as people get older, and may reflect a 3 reduction in dopaminergic signaling. The present pharmacological fMRI study investigated episodic 4 memory-related dedifferentiation in young and older adults, and its relation to dopaminergic 5 function, u...

متن کامل

Lipid extrusion during dedifferentiation

Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation, whereas beef-derived adipocytes symmetrically, or asymmetrically, divide without expelling lipid. The...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Genetics

سال: 2012

ISSN: 1061-4036,1546-1718

DOI: 10.1038/ng.2486